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Seminar Information Seminar Date April 11, 2025 - 2:00 PM Location The FUNG Auditorium - PFBH Abstract Personal and population health applications built on top of large-scale mobile sensor data and computing platforms have a great potential to impact the way we diagnose diseases, track, and manage our health. However, the existing sensing […]
Single-cell technologies have emerged as powerful tools for studying development, enabling comprehensive surveys of cellular diversity at profiled timepoints. They shed light on the dynamics of regulatory element activity and gene expression changes during the emergence of each cell type. Despite their potential, nearly all atlases of embryogenesis are constrained by sampling density, i.e., the number of discrete time points at which individual embryos are harvested. This limitation affects the resolution at which regulatory transitions can be characterized. In this talk, I present a novel cell collection approach capable of constructing a continuous representation of dynamic regulatory processes. I applied this approach to generate a continuous, single-cell atlas of chromatin accessibility and gene expression spanning Drosophila embryogenesis. Additionally, I will discuss my past and future research, applying new genomic technologies to characterize gene regulation important for human diseases.
Abstract: Effective conservation and management relies on an in-depth understanding of the health of marine ecosystems. Dr. Kendall-Bar's interdisciplinary approach combines engineering, visualization, and computation to study ocean resilience in terms of the extreme physiology and behavior of marine animals, establishing eco-physiological baselines to track over time in the face of climate change. This seminar and chalk talk will review her work to create innovative tools to detect, visualize, and analyze the physiology and behavior of animals in extreme environments that showcase their biological resilience to oxygen and sleep deprivation. From individuals to ecosystems, Kendall-Bar conducts multidisciplinary physiological studies that combine basic and applied science with potential to advance conservation and comparative medicine. This seminar reviews Kendall-Bar's dissertation research on sleep in seals and presents some current and ongoing projects to combine high-performance computing, automation, and visualization to assess diving physiology in human freedivers, epilepsy in sea lions, and cardiac performance in some of the largest (blue whales) and smallest (emperor penguins) divers. Kendall-Bar’s newest projects involve novel data visualizations and science communication to inform research as well as international policy in domains ranging from marine mammal conservation to traditional ecological knowledge and coral reef restoration.
