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Abstract: Although influenza is one of the best-studied viruses, vaccine effectiveness remains around 20-50%. A sizable fraction of people exhibit a weak or short-lived antibody response following vaccination, yet we cannot identify these individuals a priori nor ascertain whether a different vaccine would have served them better. In this talk, we demonstrate how machine learning can leverage the wealth of prior studies to forecast each person’s vaccine response. We will discuss when these predictions are accurate, when they fall short, and some of the exciting possibilities for the future of this field.